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$%&s6@xh@&)@q47E??@xh@&)@q47E@r6Kg_@r6Kg_???@4(re]@r?@r6Kg_Inactive_Insulin7Beta_cells*base_beta_cell_productivity*activation_time      !# $%&s1@w+@rJs??@w+@rJs@r6Y@r6Y???@3\qp@r?@r6YActive_Insulin2Inactive_Insulin*degradation_time/activation_time       !# $%&f! @@TG[G@2tD^>A??@@TG[G@2tD^>A@4=8.@4=h,[???@4=8.@4@4=h,[secretion_from_pancreas"Beta_cells*Beta_cell_productivity     !# $%&f  @:"@2>'??@:"@2>'@4(zV@4(re]???@4(zV@4@4(re] activation!Inactive_Insulin/activation_time     !# $%&f  @8r?@3J+-T??@8r?@3J+-T@3Yx@3\qp???@3Yx@4@3\qp degradation Active_Insulin/degradation_time     !# $%&f@????? injected_insulinApulse(insulin_inject_amount,Insulin_inject_time,inject_interval)      !# $%&c@@??@@@@???@@? @glucose_release_rate4.5   @ !# $%&c @?WG91?L_%R???WG91?L_%R?D'ͮ?D'Ӡ????O/16?? ?D'Ӡimpact_of_insulininsulin_concentrationX@$@4@>@D@I@N@Q@T@V@YX????333333?\(\?zG{?=p =?\(?޸Q?(\)?=p = !# $%&c@b@b??@b@b @b@b???@b @b? @bdesired_glucose_level150 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$%&c@0c&b&@"}0)??@0c&b&@"}0)@$BcBQo@$BcBO+???@$Bl|E@$?@$BcBO+glucose_concentrationGlucose/tissue_space     !# $%&c ??JVa?/ O2???JVa?/ O2?GU|?GV????-zB5U?Q??GVuptake_fractioninsulin_concentrationX@@ @(@0@4@8@<@@@B@DX?~Q?tj~?bM?E?1&?Q?-V?l?9XbM?tj?ȴ9Xb !# $%&c@8r?@3J+-T??@8r?@3J+-T@3\@3\qp???@3Yx@4?@3\qpinsulin_concentrationActive_Insulin/tissue_space      !# $%&c @.@.??@.@.@.@.???@.@.?@. tissue_space15 !# $%&c@i@i??@i@i@i@i???@i@i?@iIVGTT_Interval200 !# $%&c @@??@@@@???@@? @ IVGTT_time5 !# S$%&c@Y@Y??@Y@Y@Y@Y???@Y@Y? @YVolume_of_IVGTT100 d!# S$%&c @4@4??@4@4@4@4???@4@4? @4inject_interval20  !# S$%&c!?????? insulin_inject_amount0  !# S$%&c"@@??@@@@???@@? @Insulin_inject_time5  !# S$%&c #@@@@??@@@@@@@@???@@@@? @@ Beta_cells1000 !# S$%&c$@.@.??@.@.@.@.???@.@.?@.degradation_time15 !# $%&c%@.@.??@.@.@.@.???@.@.?@.activation_time15 !# $%&c&?????? decrease_in_production0 !# S$%&c'?zG{?zG{???zG{?zG{?zG{?zG{????zG{?zG{??zG{base_beta_cell_productivity.02*(1-decrease_in_production)  ?z G{     !# $%&c-(?R2?妅9???R2?妅9?l,t^?l,r݌????t]?zG{??l,r݌Beta_cell_productivity.base_beta_cell_productivity*effect_of_glucose     !# $%&c @)? %>q?0??? %>q?0?0܂?0܂????0`%Yi???0܂effect_of_glucoseglucose_concentrationX@@$@.@4@9@>@A@D@F@IX?p =q??\(\?zG@Q@\(@(\)@ zG@ \(\@ =p !# $%&  o!  @'a D @ ()* Graph 1+, S'JHu@"^()*+-hh @@@@@@d8?./01# # , S' tJa@Ja= 'BYE()*('Patient variables: Decrease in Production determines how productive beta cells are producing insulin (0 is normal level) Beta cells determines how many beta cells are available for insulin production (1000 is normal) Test Variables: The IVGTT (intravenous glucose tolerance test ) basically injects a large amount of glucose into a person's bloodstream. If the person has diabetes, he will not be able to stabilize his blood sugar, and will need insulin injected. The variables determine how much sugar, and what time (in minutes) to inject it. Insulin Injection variables: These variables determine how much insulin is injected, when and how often. This will depend on the patient variables. If too little is injected into a diabetic, or too late, the person will go into diabetic shock. If too much is injected, the person will go into a diabetic coma. The doctors' problem: figure out how much insulin to inject based on the patient's level of diabetes. For another diabetes model, see http://www.2aida.org/aida/options.htm for an online simulation+, S'JJ@ii$)`()*+-??8?./01# # , S'J@\\4()*+-@i@Y@Y28?./01# # , S'J@/()*+-@i@$8?./01# # , S'J@.)()*+-@$@@28?./01# # , S'JS@-1i()*+-@b@4@4 8?./01# # , S' t!@! (()* Patient Variables:+, S'M@h  p()*+, S'J!@ 47()*+-@$@@28?./01# # , S''M@o w()*+, S'M@o w()*+, S' t"`" ()*Test Variables:+, S' t `  ()*Insulin Injection Variables:+, Sdrmd  0uCC!   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