The Perfect Storm of Computational Biology

• "The Genomic-Revolution"

  Patterns in the sequence space >> statistical metrics and algorithms

  
  

  Living systems are dynamic, heterogeneous (very), multi-scale (in time and space), robust, information systems

  • Conversion from reductionist to integrative biology >> large scale data collection efforts
    • Kyoto Encyclopedia of Genes and Genomes
    • Physiome
    • Check systems-biology.org for more
  • Modeling and simulation efforts
    • standards movements for
      • Models (SBML and CellML)
      • Tools (SBW and PCEnv)
      • Graphical notation (SBGN)
    • Model repositories
      • Biomodels Database
      • CellML Model Repository

  • Large amounts of data and tools (and don't forget the tools)

  
  



Why has it taken biologists (en masse) so long to come around?




Patterns in biology + math(the science of patterns) = symbiotic relationship(?)